Chhoti Bahen is the story about the delicate but powerful bond of love. Rajendra and Shekhar lose their parents, and the all they have is each other, and their younger sister Meena. Though in love, Rajendra swears that he will not marry till his younger brother and sister are settled. Shekhar falls in love with a rich girl Shobha. Meanwhile, Meena's marriage is fixed. Misfortune strikes when Meena meets with an accident and is blinded forever. Shekhar, pressed on by an impatient Shobha, marries her and they go away to live with her rich father. Rajendra loses his job. To support his poor blind sister, he is desperate for a job.